abstract：BACKGROUND:Dendritic cell (DC)-based vaccination has been suggested to be promising for glioblastoma. However, the evidence in randomized controlled trials (RCTs) is inconsistent. We aimed to systematically evaluate the efficacy and safety of DC vaccine for glioblastoma via a meta-analysis of RCTs. METHODS:Related ran...

journal_title：International immunopharmacology

authors： Lv L,Huang J,Xi H,Zhou X

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is one of the autoimmune diseases, believed to be closely related to hyperactivity of B cells, overproduction of autoantibodies and immune complex formation and deposition in affected tissue. The autoreactive inflammation leads to multiorgan damage with kidney dysfunction in...

journal_title：International immunopharmacology

authors： Wardowska A,Komorniczak M,Skoniecka A,Bułło-Piontecka B,Lisowska KA,Dębska-Ślizień MA,Pikuła M

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:This study aims to select the most effective anti-Rheumatoid Arthritis (RA) component of flavonoids from Daphne genkwa Sieb. et Zucc. by anti-inflammatory and immunomodulatory effects in vitro, and to elucidate the mechanism. METHODS:The anti-inflammatory and immunomodulatory effects of total flavonoids (TF)...

journal_title：International immunopharmacology

authors： Sun YW,Bao Y,Yu H,Chen QJ,Lu F,Zhai S,Zhang CF,Li F,Wang CZ,Yuan CS

更新日期：2020-06-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

journal_title：International immunopharmacology

authors： Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Although it is widely accepted that the "hygiene hypothesis" explains the increased incidence of asthma, the lack of suitable animal models hinders further in-depth studies of the underlying molecular immune mechanisms. Therefore, we aimed to develop a robust mouse asthma model to investigate the role of bac...

journal_title：International immunopharmacology

authors： Li Y,Tu C,Chen M,Tan C,Zheng X,Wang Z,Liang Y,Wang K,Wu J,Li H,Liu J

更新日期：2020-06-01 00:00:00

abstract：:Lung cancer is the leading reason of cancer-related death from cancer globally for both men and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical outcome. However, this prognostic significance of immune cell types in lung squamous cell carcinoma (LUSC) is unclear and should be systemat...

journal_title：International immunopharmacology

authors： Xu F,Zhang H,Chen J,Lin L,Chen Y

更新日期：2020-04-01 00:00:00

abstract：:The garlic-derived organosulfur compound S-allylmercaptocysteine (SAMC) has been reported to exhibit anti-inflammatory and anti-oxidative activities, whereas its potential therapeutic effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is unknown. In this study, we focused on exploring the therapeutic e...

journal_title：International immunopharmacology

authors： Mo M,Li S,Dong Z,Li C,Sun Y,Li A,Zhao Z

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Accumulating evidence has revealed the roles of microRNAs (miRs) in sepsis, hence, the aim of the present study was to investigate whether miR-208a-5p affects sepsis whilst attempting to elucidate the mechanisms by which the suppressors of cytokine signaling 2 (SOCS2)-mediated nuclear factor-kappaB/hypoxia-i...

journal_title：International immunopharmacology

authors： Ouyang H,Tan Y,Li Q,Xia F,Xiao X,Zheng S,Lu J,Zhong J,Hu Y

更新日期：2020-04-01 00:00:00

abstract：:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumat...

journal_title：International immunopharmacology

authors： Zhang Y,Wang J,Zhang D,Lu Z,Man J

更新日期：2020-04-01 00:00:00

abstract：:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

journal_title：International immunopharmacology

authors： Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

更新日期：2020-04-01 00:00:00

abstract：:Suitable and efficient treatments for Henoch-Schönlein purpura nephritis (HSPN) with proteinuria remains unclear. Whether steroids combined with immunosuppressive agents improves prognosis compared to steroid therapy alone also remains controversial. This study explored whether combined therapy reduces proteinuria in ...

journal_title：International immunopharmacology

authors： Yu Y,Chen J,Yin H,Deng Z,Xie Y,Yuan Q,Xu H,Liu S,Tao L,Peng Z

更新日期：2020-04-01 00:00:00

abstract：BACKGROUNDS:Autoimmune myocarditis is characterized by over-activated immune system attacking the cardiomyocytes, resulting in heart function decline. In the current study, we investigated the therapeutic advantages of delivering Interleukin-10 (IL-10) by mesenchymal stem cells (MSCs), both of which had immune suppress...

journal_title：International immunopharmacology

authors： Shao M,Wang D,Zhou Y,Du K,Liu W

更新日期：2020-04-01 00:00:00

abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

journal_title：International immunopharmacology

authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

更新日期：2020-04-01 00:00:00

abstract：:Andrographolide (AG), an ingredient extracted from traditional Chinese herbal medicine Andrographis paniculata, has been demonstrated to have potent anti-inflammatory and anti-oxidative stress properties. The purpose of this study was to investigate whether and how AG attenuated CSE-induced mitochondrial dysfunction, ...

journal_title：International immunopharmacology

authors： Zhang XF,Ding MJ,Cheng C,Zhang Y,Xiang SY,Lu J,Liu ZB

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. METHODS AND MATERIALS:PAI-2 expression in MDA-MB-231con, MDA-MB-231miR-200ab and MDA-MB-231miR-200c breast cancer cells was evaluated by RT-PCR and immunofluorescence (IF), while the expression of the TAM marker F...

journal_title：International immunopharmacology

authors： Meng Z,Zhang R,Wang Y,Zhu G,Jin T,Li C,Zhang S

更新日期：2020-04-01 00:00:00

abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

journal_title：International immunopharmacology

authors： Wei F,Hao Y

更新日期：2020-03-06 00:00:00

abstract：:It is well established that there exist comprehensive interactions between tumor immunology and tumor biology. Tumor-infiltrating immune cells (TIICs) have been appealing therapeutic targets due to their significance in regulating cancer progression. The purpose of this study was to illustrate the comprehensive landsc...

journal_title：International immunopharmacology

authors： Jin Y,Qin X

更新日期：2020-03-04 00:00:00

abstract：:Proteasome inhibitor bortezomib offers one more option for acute or chronic antibody-mediated rejection after kidney transplantation, but aggravated acute kidney injury (AKI) in some cases early after surgery using bortezomib bring new problem. Here, we evaluated the effects of bortezomib and ONX-0914 on renal tubule ...

journal_title：International immunopharmacology

authors： Zhang XZ,Han F,Ding CG,Dou M,Wang YX,Xue WJ,Ding XM,Zheng J,Xu CX,Tian PX

更新日期：2020-03-03 00:00:00

abstract：OBJECTIVE:Pristimerin is known to have anti-cancer and anti-inflammatory activities; however, its therapeutic mechanism has not been described. In this study, to investigate the therapeutic mechanism of pristimerin, we examined the effect of pristimerin on TNF-α-induced endothelial inflammatory response both in vitro a...

journal_title：International immunopharmacology

authors： Liang J,Yuan S,Wang X,Lei Y,Zhang X,Huang M,Ouyang H

更新日期：2020-03-02 00:00:00

abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

journal_title：International immunopharmacology

authors： Zhang S,Bai X,Shan F

更新日期：2020-03-01 00:00:00

abstract：:Bothrops snake venoms contain biologically active components, including L-amino acid oxidases (LAAO) that induce significant leukocyte accumulation at inflammatory sites characterized by early neutrophil infiltration. As it remains unclear how snake venoms modulate neutrophil activation and chemokine production, here ...

journal_title：International immunopharmacology

authors： Pereira-Crott LS,Casare-Ogasawara TM,Ambrosio L,Chaim LFP,de Morais FR,Cintra ACO,Canicoba NC,Tucci LFF,Torqueti MR,Sampaio SV,Marzocchi-Machado CM,Castro FA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:The pathogenesis of myasthenia gravis (MG) depends upon T and B cells, as well as complement and cytokines. The activation of functional subpopulations of T and B cells is the basis of the immune response. However, the activation levels of T and B cell subsets remain unclear in the pathogenesis of MG. Here, ...

journal_title：International immunopharmacology

authors： Hu Y,Wang J,Rao J,Xu X,Cheng Y,Yan L,Wu Y,Wu N,Wu X

更新日期：2020-03-01 00:00:00

abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...

journal_title：International immunopharmacology

authors： Zhao J,Niu X,Yu J,Xiao X,Li W,Zang L,Hu Z,Siu-Po Ip P,Li W

更新日期：2020-03-01 00:00:00

abstract：:MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA-c), a mitochondrial-derived 16-amino acid peptide, targets the methionine-folate cycle, increases 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) levels, and eventually activates AMP-activated protein kinase (AMPK). AMPK activation can attenuate neutr...

journal_title：International immunopharmacology

authors： Xinqiang Y,Quan C,Yuanyuan J,Hanmei X

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia/reperfusion (I/R) injury occurs in different clinical settings as hepatic transplantation, and different types of shock. I/R injury is the main cause of hepatic damage and failure due to the production of reactive oxygen species (ROS) and inflammatory cytokines. Dimethyl fumarate (DMF), an i...

journal_title：International immunopharmacology

authors： Ibrahim SG,El-Emam SZ,Mohamed EA,Abd Ellah MF

更新日期：2020-03-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing a devastating blistering disease affecting oral and/or esophageal surfaces and, sometimes, also the skin. Anti-keratinocyte AuAbs developed by the...

journal_title：International immunopharmacology

authors： Chernyavsky A,Patel KG,Grando SA

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Increases in galactose-deficient IgA1 (Gd-IgA1) play a crucial role in the pathogenesis of IgA nephropathy (IgAN), and several recent experiments have shown that microRNAs (miRNAs) are involved in regulating the development and physiological function of the kidney. The aims of this study were to identify miRN...

journal_title：International immunopharmacology

authors： Liu D,Xia M,Liu Y,Tan X,He L,Liu Y,Chen G,Liu H

更新日期：2020-02-29 00:00:00

abstract：:Osteopontin (OPN) is a multifunctional extracellular matrix phosphoprotein that has a specific and complicated structure, and contributes to numerous physiological and pathological activities. The mechanism of OPN in many diseases has been confirmed; however, the role of OPN in myasthenia gravis (MG) remains unclear. ...

journal_title：International immunopharmacology

authors： Zhao J,Jing J,Zhao W,Li X,Hou L,Zheng C,Kong Q,Li W,Yao X,Chang L,Li H,Mu L,Wang G,Wang J

更新日期：2020-02-25 00:00:00

abstract：:Bradykinin-related peptides, the kinins, are blood-derived peptides that stimulate 2 G protein-coupled receptors, the B1 and B2 receptors (B1R, B2R). The pharmacologic and molecular identities of these 2 receptor subtypes will be succinctly reviewed herein, with emphasis on drug development, receptor expression, signa...

journal_title：International immunopharmacology

authors： Marceau F,Bachelard H,Bouthillier J,Fortin JP,Morissette G,Bawolak MT,Charest-Morin X,Gera L

更新日期：2020-02-24 00:00:00

abstract：OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

journal_title：International immunopharmacology

authors： Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

更新日期：2020-02-20 00:00:00

abstract：:Acute lung injury (ALI) is one of the severe complications in patients with traumatic brain injury (TBI), contributing to the high mortality. Ghrelin has protective effects against various inflammatory diseases, but the effects of Ghrelin on TBI-induced ALI and its mechanisms remain unknown. In this study, Ghrelin adm...

journal_title：International immunopharmacology

authors： Shao XF,Li B,Shen J,Wang QF,Chen SS,Jiang XC,Qiang D

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

journal_title：International immunopharmacology

authors： Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

更新日期：2020-02-01 00:00:00

abstract：:Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

journal_title：International immunopharmacology

authors： Yan JJ,Du GH,Qin XM,Gao L

更新日期：2020-02-01 00:00:00

abstract：:Lipopolysaccharide stimulates the intestinal microbiome to activate phosphoinositide 3 kinase (PI3K) signaling via several pathways; however, the direct effect that PI3K has on the intestinal bacterial community remains unclear. Herein, we investigate changes in the colonic microbiome of colitis PI3Kγ-knockout (PI3Kγ-...

journal_title：International immunopharmacology

authors： Li Y,Chen QQ,Yuan J,Chen Z,Du HT,Wan J

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:We conducted a meta-analysis to evaluate the predictive value of serum soluble B cell-activating factor (sBAFF) for antibody-mediated rejection (ABMR), which remains controversial. METHODS:Systematic literature search was performed in PubMed, EMBASE, Scopus, Cochrane Library, Web of Science and three Chines...

journal_title：International immunopharmacology

authors： Zhang H,Wang S,Su X,Fu Q,Li J,Wang J,Deng R,Wu C,Huang Q,Liu L,Wang C

更新日期：2020-02-01 00:00:00

abstract：:Psoriasis is an autoimmune skin disease caused by interactions between keratinocytes and immune cells, such as macrophages. CD200 is expressed on the surface of various cell types, and its receptor, CD200R1, belongs to a family of immunosuppressive receptors that are mainly expressed on myeloid cells. CD200/CD200R1 si...

journal_title：International immunopharmacology

authors： Li D,Wang Y,Tang L,Jin X,Xia C,Xu H,Hu J

更新日期：2020-01-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in cell and tissue damage. In our previous work, we found cannabinoid receptor Ⅱ...

journal_title：International immunopharmacology

authors： Zhou H,Du R,Li G,Bai Z,Ma J,Mao C,Wang J,Gui H

更新日期：2020-01-01 00:00:00

abstract：:Butyrate has multiple protective effects in inflammation-related intestinal diseases. Previous studies have found that butyrate could inhibit inflammation in rheumatoid arthritis. Inflammation is a pivotal inducement in the degeneration progress of the intervertebral disc. The anti-inflammatory treatment has an appare...

journal_title：International immunopharmacology

authors： Jia J,Nie L,Liu Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a crucial pathological type of lung cancer. Immune-infiltration of the tumor microenvironment positively associated with overall survival in LUAD. TTC21A is a gene has not reported in cancer, and the mechanism behind it is still unclear. Our study assesses TTC21A role in LUAD, v...

journal_title：International immunopharmacology

authors： Wang W,Ren S,Wang Z,Zhang C,Huang J

更新日期：2020-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

journal_title：International immunopharmacology

authors： Jin Z,Ren J,Qi S

更新日期：2020-01-01 00:00:00